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Источник: https://www.mdpi.com/1999-4915/12/2/1355. Achieving Koch Postulates
Traditional identification of a microbe as the causative agent of disease requires fulfillment of Koch’s postulates, modified by Rivers for viral diseases [37]. At the present time, the 2019-nCoV has been isolated from patients, detected by specific assays in patients, and cultured in host cells (one available sequence is identified as a passage isolate), starting to fulfill these criteria. Given the recentness of the 2019-nCoV outbreak, at this point there is no animal model available to fulfill the remaining criteria: 1) testing the capability of 2019-nCoV to cause respiratory disease in a related species, 2) re-isolating the virus from the experimentally infected animal and 3) detection of a specific immune response. These efforts will surely be an area of intense research in the coming months both in China and in CoV research laboratories around the world. Notably, generating small animal models of coronavirus disease can be difficult.
На всякий случай и данные авторов сохраню:
Плюс дата публикации - январь:Return of the Coronavirus: 2019-nCoV
by Lisa E. Gralinski (1) and Vineet D. Menachery (2,3)
1. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
2. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
3. Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA
Received: 21 January 2020 / Revised: 24 January 2020 / Accepted: 24 January 2020 / Published: 24 January 2020